Babe Ruth – 1916 Sporting News
During the peak of his career, Babe Ruth was not just one of the most famous sluggers but also one of the most famous men in the United States. As a testament to his legacy, people are still willing to pay good money to get their hands on his 1916 card from the Sporting News set. In 2016, a copy went for an incredible $717,000. A year after that, another copy fetched $550,000.

Babe Ruth – 1916 Sporting News
Ken Griffey Jr. – 1989 Upper Deck Rookie
Across the ‘90s, a lot of people believed that the 1989 rookie card for Ken Griffey Jr. in the Upper Deck would be one of the most expensive baseball cards in history. Even though this did not come true, the card is still one of the most iconic cards in the past 30 years. One with a good grade will fetch you $400.

Ken Griffey Jr. – 1989 Upper Deck Rookie